Journal of Pharmaceutical Research

Asdaq Syed Mohammed Basheeruddin ¹, Mehta Shalini Kapoor ², Saifulla Khan ²

Affiliations
1 Department of Pharmacology, Krupanidhi College of Pharamacy, Bangalore - 560 035, IN
2 Department of Pharmacognosy, Krupanidhi College of Pharamacy, Bangalore - 560 035, IN

Abstract

Tylophora indica L is important medicinal plant ofAyurvedic system of medicine and used as home remedy as cardioprotective agent without any scientific background. In this investigation an attempt was made to study the effect of methanolic extract of Tylophora indica L (HETI) on serum lipid profile. Albino rats were administered HETI (100 mg/kg&500 mg/kg) once daily orally for 30 days. Accordingly, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C) were among the parameters investigated. We also evaluated the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels as a measure of hepatic cell damages. It was found in our study that the administration of both doses of HETI to animals fed with high fat diet (HFD) lowered their serum TC, TG and LDL-C significantly, while raised the serum HDL-C. Treatment with HETI reduced serum ALT and AST levels compared to HFD groups. Further, it was also observed that the high dose of HETI significantly decreases serum TC, TG and LDL-C and increases HDL-C in animals fed with normal fat diet (NFD). Based on these data, it is concluded that the chronic administration of HETI in high dose up to 500 mg/kg has definite cardioprotective potential and these results constitute a valid scientific basis for consuming Tylophora indica L. for medicinal application.

Keywords

Methanolic Extract of Tylophora indica L, High Fat Diet, Lipid Profile, Normal Fat Diet.

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Angel Mary ¹, Y. Jyothi ¹, Saifulla Khan ¹, Anuja Ranjan ¹

Affiliations
1 Krupanidhi College of Pharmacy, 12/1 Chikkabellandur, Carmelaram Post, Bangalore - 35, IN

Abstract

Purpose: Anxiety disorders have turned out to be the most common mental health conditions prevailing all over the world. The symptoms of anxiety are very common in the community, not only affecting the younger generations but also the elderly. There have been a number of advances in the pharmacotherapy of anxiety disorders in recent decades. Normal anxiety is a kind of emotion that mainly helps to face the threats and problems awaiting an individual. But when this emotion exceeds a certain limit, it causes harm to the same individual. Thus, this paper gives an overall review on what exactly anxiety is, how is it caused and the different treatment methods used so far for anxiety. Apart from this the future aspects has also been covered in this paper.

Approaches: The data were collected from various sources like journal articles, textbooks, internet, related materials in library and databases such as pubmed, google scholar and so on.

Findings: New developments are forthcoming in the field of alternative strategies for managing anxiety and for treatment-resistant cases.

Conclusion: As a word, anxiety may seem very small to read but when it comes to a person's life it can be life threatening. There are varieties of conventional treatment methods available for anxiety and many promising therapies are yet to come.

Keywords

Anxiety Disorders, Epidemiology, Psychological Treatments, Psychotherapy, Antidepressants.

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